信步杏庭 发表于 2016-12-22 17:56:42

OncoTarget:重磅!传统的中药疗法体系或可有效治疗癌症!


[*]OncoTarget:重磅!传统的中药疗法体系或可有效治疗癌症!

来源:生物谷 2016-12-19

http://cache1.bioon.com/webeditor/uploadfile/201612/20161218213608170.jpg图片摘自:www.totalrestitution.com2016年12月19日 讯 /生物谷BIOON/ --日前,一项刊登于国际杂志OncoTarget上的研究报告中,来自加州大学洛杉矶分校的研究人员通过研究发现,一种名为TSY-1的中药疗法体系(Tianshengyuan-1)能够增加正常血细胞中端粒酶的活性,但同时会降低癌细胞中端粒酶的活性;端粒酶是负责端粒产生的关键酶类,其在正常细胞分裂的调节过程中扮演着重要角色,相关研究结果表明,基于端粒酶的疗法在治疗血细胞缺失和癌症上扮演着重要的角色。有超过80%的癌症患者机体中端粒酶的活性都会增加,而且还会出现和端粒酶功能降低或异常相关的其它医学状况,端粒酶活性的增加和降低对于治疗血细胞数量产生不足的癌症具有重要的意义;当个体的骨髓无法维持对健康血细胞的供应时,就会触发骨髓移植失败的发生,而每年骨髓移植失败影响着7/10万的个体。TSY-1疗法体系在中国长期以来用于治疗再生障碍性贫血,在再生障碍性贫血患者中,其机体不能够产生足量的血细胞,同时会出现骨髓增生异常综合征或白血病前期症状,而这些状况都和端粒酶的异常直接相关。文章中研究人员进行了长达5年的研究,他们测定了TSY-1疗法影响癌细胞系端粒酶活性的能力,这些癌细胞系包括HL-60、正常的末梢血单核和定向造血干细胞;同时研究者还利用了多种方法,比如端粒酶活性测定、细胞生长测试以及TSY-1处理的细胞的基因表达检测等技术来确定TSY-1疗法体系的作用,研究结果表明,TSY-1活性的靶点就是TERT基因,TERT是端粒酶活性的主要调节组分。本文研究结果对于后期科学家们进行临床研究来阐明中药疗法体系TSY-1在治疗癌症及血细胞缺失疾病上的效果非常重要,当然研究人员也表示后期他们将通过更为深入的研究来阐明这种中药疗法体系的作用机制及效果。(生物谷Bioon.com)Chinese herbal treatment shows signs of effectiveness in bone marrow recoveryUCLA researchers have found that a Chinese herbal regimen called TSY-1 (Tianshengyuan-1) increased telomerase activity in normal blood cells but decreased it in cancer cells. Telomerase is an enzyme responsible for the production of telomeres, which play an important role in the regulation of normal cell division. These results indicate that telomerase-based treatments may play an important role in treating both blood cell deficiency and cancer.More than 80 percent of cancers have increased telomerase activity, and other medical conditions are also associated with decreased or abnormal telomerase function. The ability to increase or decrease telomerase activity has important implications for treating cancers in which insufficient numbers of blood cells are produced. When a person's bone marrow is unable to keep up with the need for healthy blood cells, bone marrow failure is triggered. Bone marrow failure affects about seven in 100,000 people annually.TSY-1 has been used in China for many years to treat aplastic anemia, a condition in which the body stops producing enough new blood cells and myelodysplastic syndrome or preleukemia; both are associated with telomerase abnormality.

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