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标题: Blood biomarkers for Alzheimer’s disease in clinical practice and trials [打印本页]

作者: lion 时间: 2025-5-25 22:10
标题: Blood biomarkers for Alzheimer’s disease in clinical practice and trials

Abstract

Blood-based biomarkers hold great promise to revolutionize the diagnostic and prognostic

work-up of Alzheimer’s disease (AD) in clinical practice. This is very timely, considering

the recent development of anti-amyloid-β (Aβ) immunotherapies. Several assays for measuring

phosphorylated tau (p-tau) in plasma exhibit high diagnostic accuracy in distinguishing AD from

all other neurodegenerative diseases in patients with cognitive impairment. Prognostic models

based on plasma p-tau levels can also predict future development of AD dementia in patients

with mild cognitive complaints. The use of such high-performing plasma p-tau assays in the

clinical practice of specialist memory clinics would reduce the need for more costly investigations

involving cerebrospinal fluid samples or positron emission tomography. Indeed, blood-based

biomarkers already facilitate identification of individuals with pre-symptomatic AD in the context

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