Alzheimer Disease as a Clinical-Biological Construct—An International Workin...

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[size=7.4835pt]CONCLUSIONS AND RELEVANCE [size=8.4813pt]The ultimate aim of the field was to foster effective AD
[size=8.4813pt]treatments, including preventing symptoms and dementia. The approach of diagnosing
[size=8.4813pt]AD without a clinical and biological construct would be unwarranted and potentially
[size=8.4813pt]concerning without a clear knowledge of when or whether symptoms will ever develop.
[size=8.4813pt]It is recommended that those who are amyloid-positive only and, more generally, most
[size=8.4813pt]biomarker-positive cognitively normal individuals, should not be labeled as having AD.
[size=8.4813pt]Rather, they should be considered as being at risk for AD. The expansion of presymptomatic
[size=8.4813pt]AD is viewed as a better diagnostic construct for those with a specific pattern of biomarkers,
[size=8.4813pt]indicating that they are proximate to the expression of symptoms in the near future